Posts by: Maureen Newman

Maureen Newman

Maureen Newman currently works as a PhD student studying biomedical engineering at University of Rochester, working towards a career of research in biomaterials for drug delivery and regenerative medicine. She is an integral part of Dr. Danielle Benoit’s laboratory, where she is investigating bone-homing therapeutics for osteoporosis treatment.

September 10, 2015September 10, 2015

New Protein TMIGD1 Protects Renal Cells from Injury

News

A new protein discovered at Boston University School of Medicine (BUSM) in the laboratory of Nader Rahimi, PhD, may change the way patients with chronic kidney disease are treated. In ... Read more

August 4, 2015August 4, 2015

Genes Associated With Kidney Disease Identified With Sequencing Techniques

News

For many diseases, the basis of disease development and progression lies in the genes. Renal disease is no different, with some individuals more prone to disease than others as a ... Read more

July 29, 2015August 3, 2015

Uric Acid Predicts CKD Progression in Children

News

Adults with hyperuricemia, or excess uric acid, are well known to develop chronic kidney disease (CKD). Children can also be affected by hyperuricemia, but the association between hyperuricemia and CKD ... Read more

July 13, 2015July 13, 2015

Metformin Use in Type 2 Diabetic Chronic Kidney Disease Patients May Increase Mortality Risk

News

Metformin, a first-line treatment for type 2 diabetes, may not be appropriate in certain patients with chronic kidney disease. Researchers at Taipei Veterans General Hospital assessed metformin use in type ... Read more

July 8, 2015July 9, 2015

Oral Iron Leads to Fewer Adverse Events Than Intravenous Iron in CKD

News

Although patients with chronic kidney disease (CKD) are commonly affected by iron-deficiency anaemia, a randomized clinical trial (REVOKE) shows evidence that intravenous iron therapy may cause serious adverse events. In ... Read more

April 16, 2015April 18, 2015

Stem Cell Transplant Studied in MNGIE

Myoneurogenic gastrointestinal encephalopathy

A currently-recruiting Phase 1 clinical trial will identify if stem cell transplants are a safe treatment option for the rare disease mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). The study aims to ... Read more

April 9, 2015April 9, 2015

Whole Exome Sequencing Useful to Diagnose Leigh Syndrome

Leigh syndrome

Even if two individuals are affected by the same disease, such as Leigh syndrome, they may not have identical symptoms or causes of disease. For example, Leigh syndrome is associated ... Read more

April 6, 2015April 6, 2015

Peptide-Mediated Mitochondrial Delivery for MERRF Treatment Outlined in New Study

Myoclonic Epilepsy with Ragged Red Fibers

If myoclonic epilepsy with ragged red fibers (MERRF) syndrome is caused by at least one of four point mutations in mitochondrial DNA, then curing the disease should be as easy ... Read more

March 30, 2015March 30, 2015

Study Investigates Simple Diagnosis for Cytochrome c Oxidase Deficiency

Leigh syndrome

Children with mitochondrial disorders most commonly are deficient in cytochrome c oxidase (CIV), a protein involved in the electron transport chain the membrane of the mitochondria. The gold standard way ... Read more

March 26, 2015March 26, 2015

Peripheral Neuropathy May Indicate Mitochondrial Myopathy

Progressive external ophthalmoplegia

A simple blood or urine test, rather than an invasive muscle biopsy, may be all that is needed to diagnose mitochondrial disease in patients with peripheral neuropathy (muscle weakness or ... Read more

March 23, 2015March 23, 2015

Raptor Pharmaceuticals’ Experimental Therapy in Phase 2 / 3 Trial for Leigh Syndrome

Kearns-Sayre syndrome, Leigh syndrome, Mitochondrial DNA depletion syndrome, Progressive external ophthalmoplegia

Raptor Pharmaceuticals Inc. is looking to bring relief to a wide variety of young patients with inherited mitochondrial disease through its therapeutic called RP103 (cysteamine bitartrate delayed-release capsules). A Phase ... Read more

March 11, 2015March 11, 2015

Early Folinic Acid Supplementation Improves Symptoms of Kearns-Sayre Syndrome

Kearns-Sayre syndrome

If patients with Kearns-Sayre syndrome commonly are deficient in folate, logic would presume folinic acid therapy may benefit their symptoms. A team from Spain tested this theory in the article ... Read more

March 2, 2015March 2, 2015

Procedure Corrects Kearns-Sayre Syndrome Eyelid Drooping

Kearns-Sayre syndrome

Chronic progressive external ophthalmoplegia (CPEO) is the most common characteristic of Kearns-Sayre syndrome, which is one member of the family of mitochondrial myopathies. Patients with CPEO may benefit from bilateral ... Read more

February 24, 2015February 24, 2015

Novel Therapy for Multiple Mitochondrial Diseases Now in Clinical Trials

Friedreich's Ataxia, Kearns-Sayre syndrome, Leigh syndrome

Edison Pharmaceuticals is actively engaged in a number of phase 2 clinical trials investigating their drug candidate EPI-743 in a variety of mitochondrial respiratory chain diseases. The studies range from ... Read more